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209991

Role of Circulating Vascular Cell Adhesion Protein–1 as a Biomarker in Non-Alcoholic Fatty Liver Disease

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Last updated: 24 Dec 2024

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Abstract

Background: As a result of the obesity pandemic, non-alcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease worldwide. NAFLD is the hepatic manifestation of obesity and a precursor of and independent risk factor for type 2 diabetes. Objective: The aim of the current work was to assess the level of vascular cell adhesion molecule 1 (VCAM-1) as non-invasive diagnostic tools for diagnosis of NAFLD degree of fibrosis. Patients and Methods: This Case-Control clinical study included a total of 60 subjects, 30 patients with fatty liver disease, FLD (Group A) and 30 healthy subjects as a control (group B), attending at Internal Medicine and Hepatology Outpatient Clinic, Ain Shams University Hospitals. Group A was further subdivided into NAFLD subgroup (15 patients) and non- alcoholic steatohepatitis (NASH) subgroup (15 patients) Results: In the present study, the mean VCAM-1 was 2.392± 0.3 in NAFLD group, 9.893± 2.3 in NASH group and 1.983 ± 0.3 in control group with high statistically significant increase in NASH followed by NAFLD than in control group. Regarding to ROC curve, VCAM-1 had excellent Diagnostic performance with an AUC of 0.994. A best cut-off criterion of VCAM-1 > 7.7 ng/mL could discriminate between patients with NASH from control group with a sensitivity of 95% and specificity of 100% In our study, there was no significant correlation in between VCAM-1 and age, AST, ALT. In the present study, the significant predictors of bad outcome in patients with NAFLD and NASH were higher VCAM-1, GGT and AST levels. Conclusion: It could be concluded that the significant predictors of bad outcome in patients with NAFLD and NASH were higher VCAM-1 level, GGT and higher AST levels.  

DOI

10.21608/ejhm.2021.209991

Keywords

Circulating Vascular cell adhesion protein – 1, Non-alcoholic fatty liver disease

Authors

First Name

Ahmed

Last Name

Abo Halima

MiddleName

Samir

Affiliation

Internal medicine department faculty of medicine ain shams university

Email

dr.abohalima@hotmail.com

City

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Orcid

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First Name

Mohamed Abd EL Moghny

Last Name

Mostafa

MiddleName

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Affiliation

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Email

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City

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Orcid

-

First Name

Ahmed Ali

Last Name

El Ray

MiddleName

-

Affiliation

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Email

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City

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Orcid

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First Name

Yasser Mohamed Ali Abdelhady

Last Name

Alsaid

MiddleName

-

Affiliation

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Email

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City

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Orcid

-

First Name

Khaled

Last Name

Raafat

MiddleName

-

Affiliation

-

Email

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City

-

Orcid

-

Volume

86

Article Issue

1

Related Issue

29518

Issue Date

2022-01-01

Receive Date

2021-12-20

Publish Date

2021-10-01

Page Start

100

Page End

104

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_209991.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=209991

Order

18

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Role of Circulating Vascular Cell Adhesion Protein–1 as a Biomarker in Non-Alcoholic Fatty Liver Disease

Details

Type

Article

Created At

22 Jan 2023