Background: Following the advancements in the treatment of acne, post-acne scarring is still a widespread problem. Platelet-rich plasma (PRP) gel is one formulation with beneficial biological or medicinal qualities that aid in the management of post-acne scarring.  Objective: It was the goal of this work to evaluate the utilization of treatment of post-acne scars with micro-needling and plasma gel. Patients and Methods: Patients with post-acne scars were recruited from the university hospital's dermatology and venereology outpatient clinic. Our study was based on 23 patients (8 males= 34.8%, 15 females= 68.2%) having 3 skin types (II, III, IV); skin type III patients representing 56.2% of total patients, most of these patients have scars for less than 10 years. Dermapen has been done to the face then the PRP gel has been applied combined with micro-needling to the post-acne scars. We performed four sessions of the previous treatment with two weeks intervals then one month's follow-up. Results: The baron, as well as Goodman scale improvement significantly post-treated with Platelet Rich Plasma Gel Combined with micro-needling, where 69.6% of cases become   grade1 post-treatment, drop grade 3 to be (8.7%) post-treatment compared to (47.8%) pre-treatment the difference statistically significant p=0.022. Furthermore, all grade4 fade out post-treatment p=0.008. Conclusion: Dermapen combined with plasma gel is a promising effective therapeutic modality for atrophic acne scars.