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207265

Role of Proangiogenic Tyrosine Kinase with Immunoglobulin and Endothelial Growth Factor Homology Domains 2 Expressing Monocytes in Chronic Lymphocytic Leukemia

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Last updated: 03 Jan 2025

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Abstract

Background: Globally, highest hematologic malignancy in prevalence is considered chronic lymphocytic leukemia (CLL). The expression of angiopoietin-2 (Ang2) and tyrosine kinase with immunoglobulin and endothelial growth factor homology domains (Tie1), two critical components of the Ang-Tie2 pro-angiogenic pathway, in CLL cells has been demonstrated. Objective: Clarification of Tie2-expressing monocytes' (TEMs) involvement in the pathophysiology of CLL is the goal of this study. Patients and Methods: The study was case control, which was performed on 21 CLL patients; their age ranged from 46 to 71 with a mean of 58.2 ± 6.9, in addition to 21 age and sex matched healthy control subjects. Full medical histories, clinical examinations, and laboratory tests were conducted on all individuals. The percentage of TEMs in peripheral blood was determined by flow cytometry and their phenotypic characteristics defined as CD14+/CD16+/Tie-2+ cells. Results: Compared to the control group, there was a statistically significant increase in TEMs in the cases group. Among the cases group there was a statistical significant increase in LDH, uric acid, WBCs, reticulocyte, CD 38 β2 microglobulin and TEMS and statistical significant decrease in Hb with increase Binet stage. There was a statistical significant +ve correlation between TEMs and LDH, WBCs, reticulocytes, CD38 and β2 microglobulin. Also, there was a statistical significant negative correlation between TEMs and Hb and platelets count among the cases group. TEMs percentage had sensitivity, specificity and accuracy (100%) in diagnosis of leukemia at cut off > 20.95%. Conclusion: TEMs could be a part of CLL pathogenesis which can be a predictor of disease progression alongside with other prognostic indicators.

DOI

10.21608/ejhm.2021.207265

Keywords

Chronic lymphocytic leukemia, Tyrosine kinase with immunoglobulin and endothelial growth factor

Authors

First Name

Amira Raafat

Last Name

Elsheikh

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Orcid

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First Name

Gehan

Last Name

Abd Elkader

MiddleName

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Affiliation

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Email

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City

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Orcid

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First Name

Ahmad Sallam

Last Name

Soliman

MiddleName

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Affiliation

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City

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Orcid

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First Name

Noran Salah Eldin

Last Name

Elsabbagh

MiddleName

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Affiliation

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Email

elsabbaghnoran@gmail.com

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Volume

85

Article Issue

2

Related Issue

28296

Issue Date

2021-10-01

Receive Date

2021-12-01

Publish Date

2021-10-01

Page Start

4,138

Page End

4,142

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_207265.html

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https://ejhm.journals.ekb.eg/service?article_code=207265

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114

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Role of Proangiogenic Tyrosine Kinase with Immunoglobulin and Endothelial Growth Factor Homology Domains 2 Expressing Monocytes in Chronic Lymphocytic Leukemia

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Article

Created At

22 Jan 2023