Background: The appearance of genital warts varies. Flat or resembling raspberries or cauliflower, they can be found in a variety of shapes. They begin as little red or pink growths and can reach a diameter of four inches or more before interfering with sexual activity or delivery (in certain circumstances) (in some cases). The warts thrive in the vaginal area's moist tissues. On the external genitals and the walls of the cervix and urethra, in women, as well as on the shaft of the penis in males, they are found. Despite the availability of different therapeutic modalities, treating warts with immunotherapy is a tremendous benefit. HPV vaccination has shown promising efficacy in the treatment of genital warts. Objective: To hallmark the new guidelines of immunotherapeutic options for treatment of genital warts. Conclusion: Immunotherapy with HPV vaccines is an effective and safe treatment modality of anogenital warts.