Background: In the general population, psoriasis affects two to three percent of people and is characterized by aberrant epidermal proliferation and inflammation. Several clinical subtypes exist for it. The most prevalent form of this disorder is chronic plaque psoriasis (CPP) that is characterized by well-defined, erythematous plaques with silvery scales on knees, scalp, and elbows. There is a chance that any part of the skin could be affected. High IgE levels are frequently linked to parasite infections and atopic dermatitis, allergic contact dermatitis and bullous pemphigoid. Research suggests that psoriasis pathogenesis could be correlated with an increase in IgE expression, which could be a prospective therapy target.  Objective: Study the relation to immunoglobulin E in the pathogenesis of psoriasis. Methods: The databases were searched for articles published in English in 4 data bases [PubMed – Google scholar- science direct] and Boolean operators (and, or, not) had been used such as [Immunoglobulin E  and pathogenesis of Psoriasis OR IgE]  and in peer-reviewed articles between January 2001 and October 2020. Conclusion: Overexpression of Immunoglobulin E may have a role in the pathogenesis of psoriasis through several mechanisms. Hence, it could be a viable target to assess severity of psoriasis and follow up of treatment goals.