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205096

Platelet-rich Fibrin for Chronic Wounds Management

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Last updated: 03 Jan 2025

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Abstract

Background: A chronic wound can be defined as any wound that fails to heal within a reasonable period. Platelet-rich fibrin (PRF) is a second-generation platelet concentrate. It is safe, simple, affordable and less expensive procedure in treatment of chronic wounds. Objective: This study aimed to assess safety and effectiveness of platelet-rich fibrin for treatment of chronic wounds. Patients and methods: This prospective study included 50 patients with chronic ulcer not responding to conventional therapy for at least 6 weeks, normal values blood tests especially platelet count, red blood cell count and serum albumin level. Debridement of the necrotic tissues was done using surgical and chemical debridement. The fibrin clot membrane was applied to the ulcer followed by paraffin gauze and secondary sterile dry dressing. Results: Complete wound healing occurred in 18 of 50 patients before 8th week of therapy (36%). A decrease in the mean area was observed from 7.22 ± 5.80 cm2 before treatment to 0.98 ± 1.52 cm2 after 8 weeks of therapy, which was highly significant. Conclusions: The use of PRF is effective, simple, affordable and inexpensive method allowing acceleration of healing of chronic wounds.  

DOI

10.21608/ejhm.2021.205096

Keywords

Platelet-rich Fibrin, Chronic Wounds, diabetic foot ulcer, Critical Limb Ischemia

Authors

First Name

Mohammed Hussein

Last Name

Khalifa

MiddleName

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Affiliation

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Email

mohammedtammam28@gmail.com

City

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Orcid

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First Name

Mena Zarif

Last Name

Helmy

MiddleName

-

Affiliation

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Email

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City

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Orcid

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First Name

Asser AbdElhamed

Last Name

Goda

MiddleName

-

Affiliation

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Email

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City

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Orcid

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First Name

Kamal A. A. M.

Last Name

Hasanein

MiddleName

-

Affiliation

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Email

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City

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Orcid

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Volume

85

Article Issue

2

Related Issue

28296

Issue Date

2021-10-01

Receive Date

2021-11-16

Publish Date

2021-10-01

Page Start

3,878

Page End

3,882

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 85_Issue 2_Pages 3878-3882.pdf

PDF . 322.4kB

Link

https://ejhm.journals.ekb.eg/article_205096.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=205096

Order

70

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Platelet-rich Fibrin for Chronic Wounds Management

Details

Type

Article

Created At

22 Jan 2023