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203758

The Predictive Value of Vanin-1 in Pediatric Immune Thrombocytopenia

Article

Last updated: 03 Jan 2025

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Abstract

Background: Immune thrombocytopenia (ITP) has oxidative stress-related pathway as one of its possible mechanisms. Vanin-1 (VNN1) is an oxidative stress sensitive sensor. Objective: The present study was conducted to assess the clinical significance of VNN1 in pediatric ITP patients. Patients and Methods: A total of 50 kids with ITP have been involved in this work; 25 newly diagnosed, 25 chronic patients with ITP more than 12 months (15 responders and 10 non responders to treatment) and 25 apparently healthy children. All groups had their serum VNN-1 levels checked using a two-antibody sandwich enzyme-linked immunosorbent test. Results: The serum VNN1 level was significantly higher in ITP group than control group (p˂0.001). The level of serum VNN1 was significantly very high in newly diagnosed ITP group (p˂0.001) in comparison to chronic responders and chronic non responders ITP groups. Moreover, there was a significant increase in serum VNN1 level in chronic non responders ITP group (p˂0.001) compared to chronic responders group. In newly diagnosed ITP group, both age (r=-0.62, p=0.006) and the platelet count (r=-0.46, p=0.01) had a significant negative connection with serum VNN1 level. A cut-off value lower than 0.6 ng/ml for serum VNN1 could be used to distinguish the chronic non-responders ITP from chronic responders patients with 100 percent specificity and 90 percent sensitivity. Conclusion: From our current results, it is hypothesized that high VNN1 level plays a role in the pathogenesis and progress of pediatric ITP.  

DOI

10.21608/ejhm.2021.203758

Keywords

Oxidative Stress, pathogenesis, Pediatric ITP, Responders, Vanin-1

Authors

First Name

Mohamed

Last Name

Eissa

MiddleName

-

Affiliation

KSA, Abha, 61412, P.O. Box 641

Email

eissa20002000@yahoo.com

City

Abha

Orcid

-

First Name

Amal

Last Name

Zidan

MiddleName

-

Affiliation

-

Email

dramalzidan@yahoo.com

City

-

Orcid

-

First Name

Alaa A.

Last Name

Omran

MiddleName

-

Affiliation

-

Email

-

City

-

Orcid

-

Volume

85

Article Issue

2

Related Issue

28296

Issue Date

2021-10-01

Receive Date

2021-11-08

Publish Date

2021-10-01

Page Start

3,737

Page End

3,741

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_203758.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=203758

Order

47

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

The Predictive Value of Vanin-1 in Pediatric Immune Thrombocytopenia

Details

Type

Article

Created At

22 Jan 2023