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203751

Serum Osteopontin and its Relation to Colorectal Carcinoma in Egyptian Patient

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Last updated: 24 Dec 2024

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Abstract

Background: Colorectal cancer (CRC) incidence has increased worldwide recently, and the death rate from it has increased to reach 10% of cancer-related deaths. Many risk factors are expected to play a role in this high incidence such as the higher age, change in dietary habits, cigarettesmoking, low physical exercise, and the increased prevalence of obesity of the populations worldwide. Objectives: To evaluate the role of serum level of osteopontin in prediction of colorectal carcinoma in correlation with tissue histopathology, which is the gold standard test.
Patients and Methods: This study was conducted on 80 subjects referred for colonoscopy at the Endoscopic Unit of Ain Shams University Hospitals. Patients were divided into 2 groups: Group A included 40 patients diagnosed as colorectal carcinoma as a patient group and group B that included 40 individuals with age- and sex-matched who had normal colonoscopy and was used as control group. 
Results: The level of osteopontin was statistically significant higher in CRC patients than in subjects with normal colonoscopy. Also, the ROC curve for osteopontin in prediction of CRC showed the best cut of value of > 12 ng/ml with area under the curve (AUC) = 0.889, sensitivity = 85% and specificity = 77.5%.
Conclusion: Serum Osteopontin (OPN) level was detected in our study to be high in patients with CRC in comparison to patients with normal colonoscopy. Therefore, it can be used as a biomarker in the diagnosis of CRC. Also, serum osteopontin level is significantly higher in cancer patients with metastasis according to TNM staging, thus it can be used in prognosis.
 

DOI

10.21608/ejhm.2021.203751

Keywords

Colorectal carcinoma, Serum osteopontin, colonoscopy, histopathology

Authors

First Name

Ahmed Samir

Last Name

Allam

MiddleName

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Affiliation

Internal Medicine and Gastroenterology and Hepatology Unit Department, Faculty of Medicine, Ain Shams University, Egypt.

Email

ahm82allam@gmail.com

City

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Orcid

-

First Name

Mohamed Abd Elmoghny

Last Name

Mostafa

MiddleName

-

Affiliation

Internal Medicine and Gastroenterology and Hepatology Unit Department, Faculty of Medicine, Ain Shams University, Egypt.

Email

-

City

-

Orcid

-

First Name

Hany Haron

Last Name

Kayser

MiddleName

-

Affiliation

Internal Medicine and Gastroenterology and Hepatology Unit Department, Faculty of Medicine, Ain Shams University, Egypt.

Email

-

City

-

Orcid

-

First Name

Abanoub Refaat

Last Name

Hakim

MiddleName

-

Affiliation

Internal Medicine and Gastroenterology and Hepatology Unit Department, Faculty of Medicine, Ain Shams University, Egypt.

Email

-

City

-

Orcid

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Volume

85

Article Issue

2

Related Issue

28296

Issue Date

2021-10-01

Receive Date

2021-11-08

Publish Date

2021-10-01

Page Start

3,718

Page End

3,723

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 85_Issue 2_Pages 3718-3723.pdf

PDF . 696.8kB

Link

https://ejhm.journals.ekb.eg/article_203751.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=203751

Order

44

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Serum Osteopontin and its Relation to Colorectal Carcinoma in Egyptian Patient

Details

Type

Article

Created At

22 Jan 2023