Background: the prevalence of mood and anxiety disorders is higher among persons living with diabetes compared to those without diabetes. Numerous studies have demonstrated that both obesity and metabolic disorders are associated with depression. This study aimed to confirm the association between depression and risk factors as obesity and type 2 diabetes mellitus.Subjects and methods: This comparative cross-sectional study was carried out on 90 adults attending to the Diabetes outpatient clinic in Internal Medicine Department, Faculty of Medicine, Zagazig University Hospitals. They were divided into three groups, 30 patients with type 2 diabetes mellitus with normal body mass index (BMI), 30 obese non-diabetic individuals and 30 obese type 2 diabetic patients. Full medical history, clinical examination, laboratory investigation and assessment of depression were performed. Result: Age was 51.60±14.28, 42.26±12.21 and 51.93±9.89 respectively and Group B it was significantly younger than other two groups with no significant difference between them. No significant difference was found between groups regarding disease duration or diabetes mellitus (DM) treatment and also complication but regarding comorbidity Group C was significantly associated with comorbidity. Group A was significantly lower regarding Beck Depression Inventory and overall depression was significantly associated with group B and Group C as it was 30.0% and 46.7% respectively. Grade and overall depression were significantly associated with BMI >35 group. Conclusion: Type 2 diabetes mellitus and morbid obesity (BMI > 35) were associated with high prevalence of depression. It is evident that several modifiable and non-modifiable risk factors play an important role in the pathogenesis of diabetes and depression among population.