Background: Mirena prevents pregnancy for up to five years after insertion. It is one of several hormonal intrauterine device (IUD) with Food and Drug Administration approval. Like the progestogen-related mental side effects, is still a rather unexplored scientific field? Objective: the present study aimed to assess the perception effects of mirena intrauterine contraceptives (IUC) and the actual sexual functioning, weight gain and mood changes level. Patients and Methods: this study included 46 women, using an intrauterine contraceptive method. The study was conducted in Obstetrics and Gynecology Department, Zagazig University Hospitals. All patients who enrolled in the study were subjected to full history taking, clinical examinations, and estimation of female sexual function index and BMI. Main outcomes was estimated including desire, orgasmic function, lubrication and vulvovaginal symptoms, sexual satisfaction and mood changes. Results: About 19.6% of the studied group had no pain during insertion, 36.9% had mild pain, 36.9% had moderate pain and 6.6% had high pain. Mean pain score was 4 ± 1.8 with range from 0 to 8. Most frequent complication among the studied group were vulvovaginitis (52.2%) followed by abdominal and pelvic pain (37%). Only 6.5% had heavy menstrual bleeding and no cases had uterine perforation during insertion. Conclusion: Using of mirena IUD type is not associated with changes related to sexuality of women, quality of life and body weight gain.