Background: a lingering disease of inflammatory type called oral lichen planus (OLP) affects the oral mucosa. It can be presented at one of the following forms: ulcerative, erosive, hyperkeratotic and reticular form. Patients usually feel discomfort, burning sensation, pain and changes of the life quality. Mostly it affects women of middle ages and to a lesser extent affects children. There are many therapeutic modalities in treatment of OLP but mostly no effective results are obtained and patient satisfaction is poor and recurrence occurred. Intralesional platelet-rich plasma is used to treat erosive dermatological lesion, it depends on its high concentration of growth factors that prompt healing. Objective: To study the effect of intralesional platelet-rich plasma in the treatment of oral lichen planus. Conclusion: Intralesional platelet-rich plasma is a good and safe modality for treatment of oral lichen planus