Background: Breast cancer is the second most common cancer among women, with an estimated 3.5 million survivors as of 2015. There is continuous annual improvement of the overall survival of breast cancer patients, with 5-year overall survival estimates increasing from 84.6% to 90.9% over the previous two decades. Objective: The aim of the current work was to improve aesthetic satisfaction and oncological outcome of patients with breast outer quadrant tumors. Patients and Methods: This interventional study included a total of 18 cases with early breast cancer at upper and lower-outer quadrants of breast, attending at Onco-Surgery Unit, General Surgery Department, Faculty of Medicine, Zagazig University. This study was conducted between December 2020 to May 2021. All patients were subjected to demographic data taking, complete clinical examination, and investigations including imaging, biopsies, and histopathology. Results: The Histopathological type of tumor, all of them had Invasive ductal carcinoma. Most of the tumors were (ER) and (PR) Positive with HER2/neo Negative. The mean duration of operation was 86.94±10.45 (range 70–105) minute and the mean blood loss was 286±12.34 (range 250-315) milliliter and all patients had no intraoperative complication. Conclusions: It could be concluded that the vertical axillary incision is a safe and effective approach for the management of tumors of the outer quadrant of the breast; and cosmetically appropriate maneuver for these tumors.