Background: There are several organized factors which influence the development of diabetes among HCV-infected patients like age, sex, and family history of diabetes. Patients with diabetes mellitus type 2 (T2DM) have higher risk to be infected with hepatic viruses, as hepatitis B or C virus. Objective: This study aimed to notice the prevalence of HCV and cytomegalovirus in patients with type 2 diabetes mellitus. Patients and methods: A case-control study included 95 patients with T2DM and 95 apparently healthy individuals. We evaluated the seroprevalence of two viral antibodies including (CMV IgG, HCV IgG) beside Hepatitis B surface antigen (HBsAg) in patients with T2DM in comparison to the control group. Results: There was a significant increase in HCVAb (IgG) positive patients in diabetic group compared to control group < strong>. There was a significant association between HCVAb (IgG) with systolic blood pressure (mmHg), diastolic blood pressure (mmHg), mean arterial blood pressure (mmHg), WBCs, platelets and ALT. There was a significant association between CMV IgG with age, systolic blood pressure, and mean arterial blood pressure.There was a significant association between HBV Ag with ALT, AST. Conclusion: Seropositive of anti-HCV and CMV IgG were presented in higher rate on T2DM patients than control. This confirmed a strong association between HCV, and cytomegalovirus among T2DM patients.