Background: Acne vulgaris is an inflammatory disorder of the pilosebaceous unit, which runs a chronic course and it is self-limiting.  Glycolic Acid (GA) peels need to be neutralized to have their action stopped. Neutralizing agents for alpha hydroxy acid (AHA) peels are basic solutions, such as ammonium salts, sodium bicarbonate, sodium hydroxide, or water. Buffered glycolic acid has been clinically proven to dilute the concentrated effect of acids when applied topically. Glycolic acid peels have anti-inflammatory, keratolytic, and antioxidant effects. GA targets the corneosome by enhancing breakdown and decreasing cohesiveness, causing desquamation. Objective: To assess buffered 50% GA (pH 3.0) and 0.5% salicylic acid (SA) solution in treatment of acne vulgaris. Patients and methods: A dermatological examination had been done for 24 participants. Acne severity was assessed as mild, moderate, and severe according to Global Acne Grading System (GAGS). For every case, treatment by buffered 50% GA and 0.5% SA solution was tested and evaluated. Results: After treatment with buffered 50% glycolic acid and 0.5% salicylic acid, 54.2% of acne lesion showed excellent improvement, 25.0% showed good improvement, 16.7% of acne lesion showed moderate improvement and 4.1% showed poor improvement. Conclusion: Buffered glycolic acid 50% and salicylic acid in treatment of mild to moderate degree acne vulgaris is very effective with few adverse effects.