Background: Acute kidney injury (AKI) is a common clinical situation with serious complications with long-term and short-term negative consequences as regards morbidity and mortality. Objective: To determine the short-term outcome of AKI among those patients and to evaluate the relationship between patient characteristics and the outcome of AKI. Patients and methods: A prospective study that was conducted on 70 Patients diagnosed with AKI using the Kidney Disease–Improving Global Outcomes (KDIGO) criteria based on serum creatinine (increase in serum creatinine by ≥ 0.3 mg/dL within 48h or increase in serum creatinine to ≥1.5 times baseline), which is known or presumed to have occurred within the prior 7 days. They were admitted to Internal Medicine Department, Sohag University Hospital from December 2019 to May 2020. Results: There was statistically significant relationship between patient age, history of diabetes, established chronic kidney disease (CKD) and AKI outcomes. Also there was statistically significant relation between AKI outcome and increased s. creatinine level, elevated white blood cells count, decreased hemoglobin level and increased serum potassium level. As regards the staging of AKI, We found statistically significant relationship between AKI outcomes and staging of studied population as stage 3 had worse outcomes. Also we found statistically significant relationship between AKI outcome and ultrasound grading of echogenicity of studied population as increased echogenicity had worse outcome than normal kidneys. Conclusions: Our study concluded that mortality and morbidity in patients with AKI were increased in advanced age, diabetics, CKD patients, patients with anemia, leucocytosis hyperkalemia and increased serum creatinine.