Background: Lisfranc fractures are rare injuries, with reported incidence of 0.2% of all fractures and 1/55,000 per year incidence in the population. These are reported to occur 2–4 times more commonly in men, and the peak incidence is in the third decade of life. Objective: This study was aimed to assess the functional outcome of using open reduction and internal fixation in management of ligamentous Lisfranc injuries. Patients and Methods: This prospective operative study was conducted on 18 patients with Displaced Lisfranc injury admitted to the Orthopedic Surgery Department, Faculty of Medicine, Zagazig University, during the period from February 2021 to August 2021. The diagnosis was made by medical history taking, clinical examination and radiological assessment. Results: The mean operation time was 140.0±27.43 minutes with minimum 90 and maximum 200 minutes and mean hospital stay was 4.38±1.33 with minimum 3 and maximum 8 days. The mean healing time 8.38±2.45 with minimum 6 and maximum 16 weeks. The most prevalent complication was infection (22.2%), Transient numbness (5.6%), Delay healing (5.6%), Loss reduction (5.6%) and overall complicated cases were 5 cases 27.8%. Conclusion: It could be concluded that anatomical reduction of Lisfranc injury can be achieved by open reduction and internal fixation with the Kirschner wires (K-wires) and Cannulated Screws.