Background: One of the most important measures of scientific progress in any country in the present days is the research situation. Medical students should be equipped with ample skills and knowledge about conducting research to become an efficient researcher.  Objective: This study aimed to upgrade scientific research among medical students of Faculty of Medicine, Zagazig University to assess the effect of educational training program on knowledge, attitude and skills of research. Patients and Methods: A randomized-controlled trial (an interventional study) was conducted among 110 first grade medical students. The sample was divided randomly into 2 groups: Intervention group included 55 students received the educational training program and control group that included 55 students. This study done on 3 phases: In the pre-intervention phase: knowledge, attitude and skills of research were assessed among all studied sample. Then the intervention group underwent the educational training program. Lastly in the post-intervention phase; knowledge, attitude and skills of research were assessed among both groups. Results: There was statistically significant difference of knowledge, attitude and skills of research between intervention group and control group at post-intervention phase (P<0.05). Also, there was statistically significant difference of knowledge, attitude and skills in intervention group pre- and post-intervention (P < 0.05). Conclusion: The educational training program was effective in improving levels of knowledge, attitude and skills of research among the first grade medical students.