Background: Obesity is one of the comorbid conditions which can affect the operative and postoperative outcome of patients undergoing surgery. Objective: The aim of the current work was to assess the impact of using specific protocol suggested by author included (saline wash, suture material, subcutaneous drain and binder) on wound complications after major gynecologic Oncology surgeries in obese patients. Patients and Methods: This study was an intervention prospective study which included 86 women undergoing surgical gynecologic procedures via a vertical abdominal incision performed at Obstetrics and Gynecology Department, Faculty of Medicine, Zagazig University Hospital during the period from April 2020 to October 2020. All patients were subjected to detailed history taking, Clinical examination including general, abdominal and pelvic examination. Surgical Protocol for skin closure was applied. Results: There was a significant difference between study group and control group regarding wound complications (P=0.001). Fever was found in 23.2% in study group and 34.8% in control group, seroma was found in 100% in study group and 80% in control group and wound dehiscence, wound infection and wound hematoma respectively were found in 100% in study group and 60% in control group. Conclusion: It could be concluded that using this specific protocol (saline wash, suture material (Polydioxanone Suture), subcutaneous drain and binder) may decrease the incidence of wound complications in obese women undergoing a gynecologic procedure via a vertical abdominal incision.