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189608

Efficacy and Safety of Intralesional Triamcinolone Acetonide Injection in The Treatment of Alopecia Areata

Article

Last updated: 03 Jan 2025

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Abstract

Background: Alopecia areata (AA) is a chronic, immune mediated inflammatory disorder of anagen hair follicles leading to relapsing, nonscarring hair loss. Many therapies are available for the treatment of AA, including topical, systemic, and injectable modalities however, these treatment methods produce variable clinical outcomes and there are no currently available treatments that induce and sustain remission. Intralesional injection of corticosteroids (ILCs) is considered relatively simple, effective, and minimally invasive. Objective: The aim of the work wasto investigate the efficacy and safety of intralesional Triamcinolone acetonide injection in the treatment of AA. Patients and methods: Thirty-six patients suffering from AA were included in the study. All patients were subjected to complete history taking, general examination and dermatological examination for evaluation of site, size of the patches and type of Alopecia. Confirmation of diagnosis was done by dermoscopy. Evaluation of severity of the disease using SALT scoring system was done. After that, all the patients were treated by ILCs (Triamcinolone acetonide).  5 mg/ml of Triamcinolone acetonide was injected and the Injections were repeated every 4 weeks. Patients were assessed clinically at baseline and every month till the end of the sessions and were asked about their satisfaction on hair growth.  Side effects were also monitored every session during and after injection. Results: Hair growth after Intralesional Triamcinolone Acetonide treatment ranged from 0 to 5. 5.6% of patients showed excellent response, 5.6% showed very good response, 55.6% showed good response, 5.6% showed moderate response, 16.7% showed mild response while four patients showed poor response. Side effects were minimal like pain and atrophy (11.1%). Conclusion: Intralesional Triamcinolone acetonide injection is safe and effective in the treatment of alopecia areata.  

DOI

10.21608/ejhm.2021.189608

Keywords

Alopecia Areata, Triamcinolone acetonide, Intralesional corticosteroids, SALT scoring

Authors

First Name

Esraa Wathab

Last Name

Abdel Fatah

MiddleName

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Affiliation

Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Zagazig University, Egypt.

Email

esraa.wesab@su.edu.eg

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Orcid

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First Name

Ahmed Said

Last Name

Abdel Shafy

MiddleName

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Affiliation

Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Zagazig University, Egypt.

Email

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Orcid

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First Name

Shrook Abd Elshafy

Last Name

Khashaba

MiddleName

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Affiliation

Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Zagazig University, Egypt.

Email

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City

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Orcid

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Volume

84

Article Issue

1

Related Issue

25405

Issue Date

2021-07-01

Receive Date

2021-08-16

Publish Date

2021-07-01

Page Start

2,633

Page End

2,636

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_189608.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=189608

Order

161

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Efficacy and Safety of Intralesional Triamcinolone Acetonide Injection in The Treatment of Alopecia Areata

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Article

Created At

22 Jan 2023