Background: Hypertrophic scar (HTS) formation after burn remains a major issue for burned patients and is considered a huge problem for clinicians because the hypertrophic scar is painful, reddish, elevated, pruritic, and aesthetically unacceptable. Objective: To evaluate the therapeutic efficacy of Cybele Scagel phonophoresis on the treatment of hypertrophic scar post burn cases. Patients and methods: Thirty patients who had hypertrophic scar after wound closure with ages ranged from 20 to 45 years were selected randomly and divided into two equal groups in number (15 patients each). Group A (study group): received Cybele scagel phonophoresis, 3 sessions per week for 8 weeks (24 sessions), while patients in group B (control group): received topical cybele scagel for 8 weeks. Methods of assessment before and after the study included Modified Vancouver scar scale (VSS) to assess hypertrophic scar characteristics (height, vascularity, pigmentation and pliability) and digital imaging for visual assessment of the scars. Results: the results of the study showed that between groups comparison, there was no significant difference in VSS between both groups pre-treatment (p > 0.05). Comparison between group A and group B post-treatment revealed a significant decrease in VSS of the group A compared to that of group B (p > 0.05). Conclusion: It could be concluded that Cybele Scagel phonophoresis is an effective and safe modality that can be used for improving appearance of post burn hypertrophic scar.