Background: Chronic haemodialysis patients are at high risk for infection because the process of haemodialysis (HM) requires vascular access for prolonged periods. The humanCytomegalo Virus (CMV) is a DNA virus belonging to the Herpesviridae family, Betaherpsvirnae subfamily and Cytomegalo virus gender, known as Human Herpes Virus Type 5, one of the main causes of morbidity. Acute CMV infection is characterized by system-wide viremia after which latency and lifelong persistence is established in selected cells such as CD34+ monocytes and hematopoietic progenitor cells in humans. Objective: The work was designed for early detection of CMV infection and metabolic syndrome (MetS) in patients on HD. Patients and Methods: In this cross-sectional study, 80 patients under regular HD due to end-stage renal disease (ESRD) had participated in the study from HD Unite of Nasr City Health Insurance Hospital in Cairo in the period from June 2019 to December 2019.   Results: In the present study, patients were divided into three groups, first group 78 patients were positive for CMV IgG (97.5%), second group 11 patients were positive for CMV IgM (13.8%) and third group 10 patients were positive for both IgG and IgM (12.3%). In our studythe females have more CMV antibodies. In the present study, patients with metabolic syndrome were 68 (85%).  Patients who had MetS and CMV IgG were 68 (100%). The relationship between MetS and CMV IgG is statistically proved. Conclusion:  the importance of early investigation for metabolic syndrome components especially in patients who are immunocompromised like HD patients because of the high prevalence of both chronic CMV infection and reactivation.