Background: Male obesity with or without smoking and raised male BMI can markedly harm quality embryo blastocyst development, clinical pregnancy rate, and live birth rate in couples who underwent in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). Male BMI could be an essential factor influencing IVF–ICSI outcome. Objective: This study aimed to investigate the effect of smoking on semen quality, fertilization, embryo quality, and their impact on pregnancy after ICSI in overweight men. Material and methods: The study was performed on 150 cases in the assisted reproductive unit in International Islamic Center for Population Studies and Research, Al-Azhar University. The recruited males were divided into three groups (50/group): Normal control (C), Overweight (OW), and overweight with a smoking (OW&S). Their physiological, biochemical, and semen parameters were investigated for all cases. The fertilization rate, cleavage rate, embryo quality, and pregnancy rate were examined and recorded during and after the ICSI process. Results: Percent of abnormal sperm morphology in the OW&S group showed a very highly significant increase (P<0.01) than the control group. However, for the overweight with smoking (OW&S) and overweight groups (OW), the percentage of the fertilization rate and the high-quality embryos were significantly lower than the values of the control group (P<0.01). The percentage of the low-quality embryo was higher in OW&S and OW groups than in the control group. The lowest rate of positive pregnancy test recorded in overweight with smoking (46%) followed by overweight (60%). Conclusion: the semen parameters and hormonal profile, fertilization rate, embryo quality, and pregnancy rate were significantly lower in smoker men suffering from overweight.