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177253

Chemerin As A Non-Invasive Serum Marker for Non-Alcoholic Fatty Liver Disease

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Last updated: 03 Jan 2025

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Abstract

Background: Attempts have been made to recognize noninvasive markers for the identification of non-alcoholic fatty liver disease (NAFLD). Chemerin is a newly defined adipokine linked to insulin resistance and adipogenesis. Objective: This study intended to evaluate the diagnostic ability of serum chemerin compared with NAFLD fibrosis score as a noninvasive marker for the diagnosis and grading of NAFLD. Patients and methods: We enrolled 60 NAFLD patients and categorized them into 3 subgroups based on the fatty liver grade by ultrasound. Thirty healthy participants were recruited as a control group. ELISA method was used for serum chemerin levels measurement. Results: Serum chemerin levels were significantly higher in NAFLD cases than controls (p ≤ 0.001). Furthermore, these levels were positively correlated with the fatty liver grade (p ≤ 0.001). Serum chemerin was comparable to NAFLD fibrosis score as regards NAFLD diagnosis (p ≤ 0.001). Patients within the gray zone of NAFLD fibrosis score had a significantly higher serum chemerin levels in comparison to patients under the gray zone (p ≤ 0.001). Conclusion: Serum chemerin is a promising marker for diagnosing and grading of NAFLD. More research is required to determine its definitive clinical benefit in patients with NAFLD.  

DOI

10.21608/ejhm.2021.177253

Keywords

Non-alcoholic fatty liver disease, Chemerin, Adipokines, Obesity, NAFLD fibrosis score

Authors

First Name

Ghada

Last Name

Mohamed

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Email

ghadaabdelrahman@med.asu.edu.eg

City

-

Orcid

0000-0003-0320-1011

First Name

Mohamed M

Last Name

Salama

MiddleName

-

Affiliation

Ghada Abdelrahman Mohamed, Gastroenterology and Hepatology Unit, Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo

Email

-

City

-

Orcid

-

First Name

Essam

Last Name

Byoumy

MiddleName

-

Affiliation

Ghada Abdelrahman Mohamed, Gastroenterology and Hepatology Unit, Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo

Email

-

City

-

Orcid

-

First Name

Azza

Last Name

Mohamed

MiddleName

-

Affiliation

Ghada Abdelrahman Mohamed, Gastroenterology and Hepatology Unit, Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo

Email

-

City

-

Orcid

-

First Name

Wesam

Last Name

Ibrahim

MiddleName

-

Affiliation

Ghada Abdelrahman Mohamed, Gastroenterology and Hepatology Unit, Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo

Email

-

City

-

Orcid

-

First Name

Ahmed

Last Name

El-shafie

MiddleName

-

Affiliation

Ghada Abdelrahman Mohamed, Gastroenterology and Hepatology Unit, Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Abdallah

MiddleName

-

Affiliation

Ghada Abdelrahman Mohamed, Gastroenterology and Hepatology Unit, Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo

Email

-

City

-

Orcid

-

Volume

84

Article Issue

1

Related Issue

25405

Issue Date

2021-07-01

Receive Date

2021-06-12

Publish Date

2021-07-01

Page Start

1,786

Page End

1,790

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 84_Issue 1_Pages 1786-1790.pdf

PDF . 348.5kB

Link

https://ejhm.journals.ekb.eg/article_177253.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=177253

Order

24

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Chemerin As A Non-Invasive Serum Marker for Non-Alcoholic Fatty Liver Disease

Details

Type

Article

Created At

22 Jan 2023