Background: Psoriasis is one of the most common immune-mediated chronic inflammatory skin disorders. Sexual dysfunction in psoriasis is influenced by factors such as the severity of psoriasis, psoriasis body area and associated physical and/ or psychic comorbidities. Objective: The study aimed to assess female sexual dysfunction and their correlation with psoriasis severity. Patients and Methods: The present study was conducted on two groups: patient group that included 30 female patients with psoriasis, with age ranged from 20-60 years old and control group included 20 healthy females, with matched age. The disease severity was graded according to the Psoriasis Area and Severity Index (PASI) score. Female sexual function was assessed by female sexual function Index (FSFI). Results: The mean of all six FSFI domains were lower in psoriatic group than in control group except pain was increased and with no statistically significant difference between both groups. Orgasm was found to be significantly decreased in female patients with psoriasis than control group. There was a significant negative correlation between female sexual function index (FSFI) and psoriasis severity (PASI). There was a significant negative correlation between age and FSFI among control group. In contrast to psoriasis group, there was no correlation between FSFI and either age or duration of disease. Conclusion: There was asignificant negative correlation between FSFI and PASI.