Background: Laparoscopic Cholecystectomy is one of the most common surgical procedures. Quality of life (QOL) is a concept reflecting physical, social, and emotional attitudes. Surgical operation, as a traumatic treatment procedure, could affect QOL of the patients as well as treating them. Therefore, surgeons should try their best to improve patient's QOL in addition to focus on the more traditional outcomes of mortality, morbidity, and laboratory findings. Objectives: The aims of the current work were to determine risk factors for calcular cholecystitis and assess the determinants of quality of life after laparoscopic cholecystectomy. Patients and methods: This cross-sectional study included a total of 200 patients prepared for laparoscopic cholecystectomy, attending at Department of Surgery, Menoufia University Hospital, Egypt. Patients were first introduced and consented for the study at the surgery outpatients' clinics during the preoperative settings and guided to fill out the chosen questionnaires and filling out other important information. Patients' understanding and readiness to fill out the questionnaire without help were assessed. Assistance was offered accordingly. Results: The demographic of the studied population shows predominant female distribution which was about three times their fellow Males. Mean age was 43 years. Presence of comorbidity in 41.5% of patients. There was a statistically significant difference between the preoperative scores and 3 months postoperative in all domains as the total score of Gastrointestinal Quality of Life index (GIQLI) improved by about ten points. Conclusion: It could be concluded thatwith no doubt laparoscopic cholecystectomy positively affected the Quality of life. Patients subjectively had significant improvement of their symptoms. Some social determinants can predict postoperative outcomes.