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170520

Interleukin-35 Level in Acne Vulgaris

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Last updated: 03 Jan 2025

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Abstract

Background: Acne vulgaris is a multifactorial disease affects the pilosebaceous follicle and results in inflammatory and non-inflammatory lesions with certain role of cytokines in its pathogenesis. Interleukin-35 (IL-35) cytokine has been shown to exhibit immunosuppressive activities, which are distinct from other members of IL-12 family. IL-35 is also unique in that it is expressed primarily by regulatory T- cells (Tregs) rather than by antigen-presenting cells (APCs). Objective: To investigate the role of IL-35 in the pathogenesis of acne vulgaris by assessing its levels in lesional skin and serum of patients with acne vulgaris compared with normal individuals. Patients and methods: 44 subjects were divided into 2 groups: Group 1: It included measurement of serum and tissue level of interleukin 35 in 22 acne vulgaris patients with age group (15-30). All of them were subjected to detailed history taking, dermatological and general examination. Group 2: It included 22 healthy, age, and gender matched individuals as a control group. Result:Our results show a highly statistically significant difference between acne patient and control regarding IL-35 level in serum and tissue. Conclusion: Our study may provide evidence that serum and tissue IL-35 are important anti-inflammatory cytokines. They are actively expressed by the sebaceous glands. They have significant higher expression in acne patients. They are hypothesized to play a key role in acne cure at multiple points, through their anti-inflammatory action. This effect may be hindered in acne vulgaris by undiscovered obstacles.

DOI

10.21608/ejhm.2021.170520

Keywords

Acne vulgaris and cytokines, IL-35 anti-inflammatory cytokine

Authors

First Name

Talal Ahmed

Last Name

Abd El-Raheem

MiddleName

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Affiliation

Department of Dermatology, STDs and Andrology, Faculty of Medicine, Fayoum University, Egypt

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First Name

Mohamed Hassan

Last Name

Mohamed

MiddleName

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Affiliation

Department of Dermatology, STDs and Andrology, Faculty of Medicine, Fayoum University, Egypt

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Orcid

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First Name

Olfat Gmeel

Last Name

Shaker

MiddleName

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Affiliation

Department of Biochemistry, Faculty of Medicine, Cairo University, Egypt

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Orcid

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First Name

Haiba Ali

Last Name

Mohamed

MiddleName

-

Affiliation

Department of Dermatology, STDs and Andrology, Faculty of Medicine, Fayoum University, Egypt

Email

haibaaly@gmail.com

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Volume

83

Article Issue

1

Related Issue

23025

Issue Date

2021-04-01

Receive Date

2021-05-18

Publish Date

2021-04-01

Page Start

1,509

Page End

1,513

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 83_Issue 1_Pages 1509-1513.pdf

PDF . 373.5kB

Link

https://ejhm.journals.ekb.eg/article_170520.html

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https://ejhm.journals.ekb.eg/service?article_code=170520

Order

108

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Interleukin-35 Level in Acne Vulgaris

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Article

Created At

22 Jan 2023