Background: A thorough clinical breast examination, imaging, and tissue sampling are needed for a definitive diagnosis of breast diseases. Contrast-enhanced digital mammography (CEDM) is the second type of advanced technology stemming from the digital platform (the first being tomosynthesis) that proved to be promising in this field. Objectives: The aim of this study was to evaluate the role of contrast enhanced digital mammography in diagnosis of breast masses. Patients and Methods: The study included 30 participants who visited the hospital for assessing their complaints of breast masses during the period from May 2019 to May 2020 after taking their consent. Results: The contrast enhanced digital mammography (CEDM) proved that 17 patients (56.7%) proved with malignant masses, 10 (33.3%) benign and 3 (10%) normal that was confirmed by final diagnosis of these cases. The sensitivity and specificity of the CEDM (100%, 92.86%) respectively, that expresses high levels of both parameters. Conclusion: CEDM has higher diagnostic value that can enhance the process of early cancer diagnosis, postoperative follow up, and treatment plans.