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168268

The Effect of Different Induction Therapies on Graft Functions in Renal Transplantation

Article

Last updated: 03 Jan 2025

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Abstract

Introduction: Rejection and delayed graft function (DGF) are frequent problems after renal transplant. The use of induction therapies increases graft survival and reduces acute rejection frequency. Here, we wanted to see one-year outcomes of patients who did not receive induction therapy and those who received basiliximab or anti-thymocyte globulin (rabbit) (rATG). Patients and Methods: 741 renal transplant recipients were divided into 3 groups: 223 patients who received rATG, 213 who received basiliximab, and 305 patients who did not receive any induction therapy. Patients' demographic characteristics, ischemia times, creatinine levels, presence of DGF and acute rejection were studied. Results: 35.6% (n=264) of the patients were female and 64.4% (n=477) were male; their ages were 4 to 72 years. During follow-up, 27 (3.6%) patients had DGF and 152 (20.5%) had acute rejection. There was no difference in DGF and rejection between the 3 groups. Conclusion: Although there wasn't statistically difference in DGF, acute rejection, or 1- year creatinine levels between groups, the rATG group had higher hemodialysis rate, longer dialysis time, lower rate of preemptive transplantation, and lower mean age.  

DOI

10.21608/ejhm.2021.168268

Keywords

Delayed graft function, Induction, rejection, Renal transplantation

Authors

First Name

Gulay

Last Name

Yilmaz

MiddleName

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Affiliation

Acıbadem International Hospital, Department of Nephrology and Transplantation, Istanbul, Turkey

Email

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City

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Orcid

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First Name

Can

Last Name

Sevinc

MiddleName

-

Affiliation

Ataturk University Faculty of Medicine Department of Internal Medicine and Nephrology, Erzurum, Turkey

Email

dr_cansevinc@yahoo.com

City

-

Orcid

0000-0002-4069-9181

Volume

83

Article Issue

1

Related Issue

23025

Issue Date

2021-04-01

Receive Date

2021-05-02

Publish Date

2021-04-01

Page Start

1,424

Page End

1,428

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_168268.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=168268

Order

95

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

The Effect of Different Induction Therapies on Graft Functions in Renal Transplantation

Details

Type

Article

Created At

22 Jan 2023