Background: While the most important sequelae of coronavirus disease 2019 (COVID- 19) are alveolar injury and respiratory failure, other systems has also been involved, particularly the renal system. The occurrence of acute kidney injury (AKI) varies broadly among patients with COVID-19 infection in various studies. Nevertheless, there is a lack of information from Middle Eastern countries. Objective: To study the effects of COVID-19 infection on kidney function and determine the predictors of AKI in those patients. Patients and Methods: The research involved 66 patients with verified diagnosis of COVID-19 infection. They were classified into group 1 (55 subjects) who did not develop AKI and group 2 (15 subjects) who developed AKI. All study participants were subjected to detailed history taking, clinical data recording and serial laboratory investigations during the time of hospital admission. Results: Both groups were sex-matched. Group 2 was significantly older than group 1 with a median age of 69 years and had lower diastolic blood pressure (DBP) than group 1. Group 2 had significantly higher acute inflammatory markers, higher serum creatinine, higher blood urea, lower serum total protein and lower estimated glomerular filtration rate (eGFR) at the time of presentation than group 1. Conclusion: AKI occurred in 22.7% of patients with verified COVID-19 infection in this study. The significant predictors of AKI in these patients were lower DBP, higher C-reactive protein level, higher serum lactate dehydrogenase level, and lower baseline eGFR.