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162853

Gross Motor Functioning in Children with Cerebral Palsy after Stem Cell Transplantation

Article

Last updated: 03 Jan 2025

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Abstract

Background Cerebral palsy (CP) is a non-progressive motor disability that mostly results from perinatal complications. It demands extensive and multidisciplinary care, which poses a burden for patients and their families and a challenge to health systems. We aimed to evaluate the effect of stem cells transplantation on gross motor functioning of CP patients.
Patients and Methods: It is a prospective study conducted on 20 children diagnosed with cerebral palsy with severe motor disability (GMFC 5) further classified into two groups according to age. The study was carried out from January 2018 to January 2020. Follow up of the patients was done before injection of stem cells and 3, 6, 9 and 12 months after injection of stem cells using Gross motor function classification scale (GMFC).
Results: The study revealed that GMFC scores in pre-injection and 3,6,9and 12 months evaluations were not statistically significant when compared among the two groups while significant improvement was found in gross motor scale from pre-injection to final injection score in each group. Median GMFC changed from 5 to 2 among all cases.
Conclusion: Gross motor function in children with CP remarkably improved after stem cell transplantation.

DOI

10.21608/ejhm.2021.162853

Keywords

transplantation, stem cells, Gross Motor, Cerebral palsy

Authors

First Name

Reham S.

Last Name

Tarkan

MiddleName

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Affiliation

Faculty of Postgraduate Childhood Studies, Ain Shams University, Cairo, Egypt

Email

rehamsabrey@chi.asu.edu.eg

City

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Orcid

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First Name

Mohamed

Last Name

Sedky

MiddleName

-

Affiliation

Faculty Of Medicine, Misr University For science and Technology

Email

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City

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Orcid

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First Name

Khaled H.

Last Name

Taman

MiddleName

-

Affiliation

Faculty of Postgraduate Childhood Studies, Ain Shams University, Cairo, Egypt

Email

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City

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Orcid

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First Name

George S.

Last Name

Kobinia

MiddleName

-

Affiliation

Stem Cell Therapy Group Vienna Medical University of Vienna –Austria

Email

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City

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Orcid

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First Name

Maisa N.

Last Name

Farid

MiddleName

-

Affiliation

Faculty of Postgraduate Childhood Studies, Ain Shams University, Cairo, Egypt

Email

-

City

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Orcid

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Volume

83

Article Issue

1

Related Issue

23025

Issue Date

2021-04-01

Receive Date

2021-04-10

Publish Date

2021-04-01

Page Start

1,215

Page End

1,217

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_162853.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=162853

Order

64

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Gross Motor Functioning in Children with Cerebral Palsy after Stem Cell Transplantation

Details

Type

Article

Created At

22 Jan 2023