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160888

Does Glucose–Insulin–Potassium Infusion during on-pump Coronary Revascularization Affect Perioperative Inotropic Requirements?

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Last updated: 03 Jan 2025

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Abstract

Background: During coronary artery bypass grafting (CABG), the myocardium is subjected to endure periods of ischemia and reperfusion, which may result in post-ischemic contractile dysfunction. That is a major contributor to early and late morbidity and mortality and increased requirement of pharmacologic and mechanical circulatory support.Glucose insulin potassium (GIK) infusion was thought to provide a cardioprotective effect. Objective: To investigate whether the use of GIK solution in patients undergoing on-pump CABG affects requirements of inotropes. Patients and Method: In this prospective, randomized placebo-controlled trial, 64 patients were assigned into two groups: the GIK group in which glucose-insulin and potassium infusion was given during CABG surgery, and the non-GIK group in which only saline infusion was given during the procedure. Results: In the GIK group, all patient needed not more than two inotropes with mean of 1.28 ± 0.46, while in the non-GIK group there were patients who need up to three inotropes with mean of 1.56 ± 0.56 (P. value of 0.032). Conclusion: GIK infusion during on-pump CABG reduces perioperative inotropic requirements.  

DOI

10.21608/ejhm.2021.160888

Keywords

CABG, cardiac protection, Inotropic support, GIK

Authors

First Name

Essam Ezzat

Last Name

Abd El-Hakeem

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City

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Orcid

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First Name

Ahmed Elsaied Abd Elrahman

Last Name

Aly

MiddleName

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Affiliation

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Email

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City

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Orcid

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First Name

Osama Salah El Din

Last Name

Mahmoud

MiddleName

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Affiliation

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Email

osamasalah@med.sohag.edu.eg

City

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Orcid

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First Name

Eman Ebraheem

Last Name

Darweesh

MiddleName

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Affiliation

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Email

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City

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Orcid

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First Name

Ahmad Hamody

Last Name

Hassan

MiddleName

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Affiliation

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Email

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City

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Orcid

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Volume

83

Article Issue

1

Related Issue

23025

Issue Date

2021-04-01

Receive Date

2021-04-03

Publish Date

2021-04-01

Page Start

1,142

Page End

1,148

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 83_Issue 1_Pages 1142-1148.pdf

PDF . 544.3kB

Link

https://ejhm.journals.ekb.eg/article_160888.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=160888

Order

52

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Does Glucose–Insulin–Potassium Infusion during on-pump Coronary Revascularization Affect Perioperative Inotropic Requirements?

Details

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Article

Created At

22 Jan 2023