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160886

Immunohistochemical Expression of Annexin A2 in Endometrial Carcinoma

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Last updated: 03 Jan 2025

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Abstract

Background: Endometrial carcinoma (EC) is second common gynecological cancer worldwide. It represents 2.83% of female genital malignancy and 72.37% of uterine corpus malignancy according to Egyptian National Cancer Institute (NCI). Distinction between endometrial atypical hyperplasia (EAH) and EC has been controversial, with clinical impact.
Objective: Investigate immunohistochemical expression of Annexin A2 (ANXA2) in EC versus endometrial proliferative lesions and correlation with available clinicopathological parameters.
Materials and Methods: This retrospective study included formalin-fixed, paraffin-embedded blocks of 66 specimens of endometrial tissue divided into four groups: EC, EAH, endometrial hyperplasia (EH) without atypia and proliferative endometrium. Immunohistochemical staining by ANXA2 antibody was done. Evaluation by semi- quantitative scores followed by correlation of results with clinicopathological data was applied.
Results: Annexin A2 was positive in all cases without significant variations between groups. Analysis using ROC curve revealed that immunohistochemical expression of ANXA2 has weak power in differentiating type I- EC from EAH. Correlation between ANXA2 expression and clinicopathological parameters in type I- EC showed a significant negative association between ANXA2 immuno-reactivity score (IRS) and maximum tumor dimension (P=0.03). On other hand, in type II- EC, there was a significant positive linear correlation between ANXA2 H-score and both maximum tumor dimension (P= 0.02) and apoptotic count (P=0.008).
Conclusion: Annexin A2 is essential for development of endometrial tissue beside carrying good features in type I- EC by its association with small tumor size. In type II- EC, ANXA2 has two opposing effects; increased tumor maximum dimension and apoptosis. Net result is in favor of increase tumor burden.

DOI

10.21608/ejhm.2021.160886

Keywords

Annexin A2, Endometrial carcinoma, Endometrial hyperplasia, Immunohistochemistry

Authors

First Name

Marwa M.

Last Name

Dawoud

MiddleName

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Affiliation

Pathology Department, Faculty of Medicine, Menofia University, Egypt

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Orcid

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First Name

Moshira M.

Last Name

Abd El-Wahed

MiddleName

-

Affiliation

Pathology Department, Faculty of Medicine, Menofia University, Egypt

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Orcid

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First Name

Ilaf M.A.

Last Name

Gaber

MiddleName

-

Affiliation

Pathology Department, Faculty of Medicine, Menofia University, Egypt

Email

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City

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Orcid

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First Name

Marwa M. Serag

Last Name

El-Dien

MiddleName

-

Affiliation

Pathology Department, Faculty of Medicine, Menofia University, Egypt

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Orcid

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Volume

83

Article Issue

1

Related Issue

23025

Issue Date

2021-04-01

Receive Date

2021-04-03

Publish Date

2021-04-01

Page Start

1,134

Page End

1,141

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 83_Issue 1_Pages 1134-1141.pdf

PDF . 665.3kB

Link

https://ejhm.journals.ekb.eg/article_160886.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=160886

Order

51

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Immunohistochemical Expression of Annexin A2 in Endometrial Carcinoma

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Article

Created At

22 Jan 2023