Background: Induction of labor has increased dramatically over the past two decades. Indications for induction of labor are either maternal (preeclampsia, pregnancy-induced hypertension) or fetal (post-term dates, growth retardation, ruptured membranes, diabetes). Objective: The purpose of this study was evaluation of the beneficial effect of isosorbide mononitrate and misoprostol for cervical ripening in induction of labor. Patients and Methods: A randomized clinical trial was carried out on 120 full-term pregnant women who were admitted for induction of labor in Zagazig University Hospitals in the period of July 2017 to March 2018. Patients were divided into two groups: Group A included 60 full term pregnant females who received 25 μg misoprostol (Vagiprost tablet) and placebo tablet in the posterior vaginal fornix. Group B included 60 full-term pregnant females who received vaginal 25 μg misoprostol (Vagiprost tablet) plus 40 mg isosorbide mononitrate (Effox tablet) in the posterior vaginal fornix. Results: There was little difference between the effectiveness of vaginal 25 mg misoprostol vaginal inserts and 40 mg isosorbide mononitrate vaginal inserts in induction of labor. The safety profiles of both drugs were similar, but isosorbide mononitrate administration is considered a low-risk method of labour induction for pregnant women at full term. Conclusions: The combination of misoprostol and isosorbide mononitrate may be more safe and effective for induction of cervical ripening in full-term pregnancy in comparison to misoprostol alone.