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156457

Evaluation of MIF as a Diagnostic Biomarker in Cases with Ankylosing Spondylitis

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Last updated: 03 Jan 2025

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Abstract

Background: Ankylosing spondylitis (AS) has been afflicting humankind as far back as ancient Egypt. Macrophage migration inhibitory factor (MIF) appears to have the unique ability to drive both inflammation and new bone formation and could play an important role in the pathogenesis of AS. Objective: The study aimed to evaluate MIF as a diagnostic biomarker in AS. Patients and Methods: This study was conducted on 42 subjects; 21 AS cases and 21 controls. Patients were subjected to full medical history, general and musculoskeletal examinations, laboratory investigations including serum MIF level, sacroiliac X-ray, sacroiliac MRI with the Ankylosing Spondylitis Disease Activity Score (ASDAS) for disease activity. Results: Regarding gender of the patients, the majority (71.4%) of patients were males; while (28.6 %) were females. We found that; the mean disease duration of AS patients was (15.05 ± 6.69) years; while the mean ASDAS score was (2.78 ± 0.68). We also found that, (71.4%) of AS patients received NSAIDs, (95.2%) received disease-modifying anti-rheumatic drugs (DMARDs), (57.1%) received tumour necrosis factor inhibitors (TNFi). Regarding imaging findings in our study, (61.9 %) of AS patients had sacroiliitis in sacroiliac X-ray while (100 %) of AS patients had sacroiliitis in sacroiliac MRI. Conclusion: Serum MIF levels are elevated in AS patients. ROC-curve analysis showed that the best cutoff point of MIF was (>41.3) with area under curve (0.625), with fair accuracy (57.1%), sensitivity (80%) and specificity (50%).  

DOI

10.21608/ejhm.2021.156457

Keywords

Biomarker AS, Evaluation, MIF

Authors

First Name

Ibrahim Tharwat

Last Name

Abdelal

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First Name

Mirvat Abdel Hameed

Last Name

Eltoukhy

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First Name

Ahmed Mohammed

Last Name

Baraka

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First Name

Mohammed Abdelrahman

Last Name

Ibrahim

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Volume

83

Article Issue

1

Related Issue

23025

Issue Date

2021-04-01

Receive Date

2021-03-14

Publish Date

2021-04-01

Page Start

851

Page End

855

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_156457.html

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https://ejhm.journals.ekb.eg/service?article_code=156457

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8

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Evaluation of MIF as a Diagnostic Biomarker in Cases with Ankylosing Spondylitis

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Article

Created At

22 Jan 2023