Background: The leading cause of morbidity and mortality among diabetic patients is cardiovascular disease (CVD). It is highly preventable with sustainable knowledge-based practice. Objectives: The aim of the current work was to assessCVD knowledge and associated factors among type 2 diabetic patients. Patients and Methods: Cross-sectional study design conducted at the outpatient department at Kasr–Alainy Hospital. Systematic random sampling method included 200 type 2 diabetic patients interviewed using questionnaire consisting of demographic characteristics, behavioral variables, and 28 items assessing key aspects of CVD knowledge. Results: seventy three percent of the patients had poor knowledge. Mean knowledge score was significantly higher among females, high educational level, non-smokers, active practicing exercise once or twice weekly and consuming fruits three or more times weekly (p < 0.01). Conclusions: Patients had insufficient CVD knowledge which can lead to unfavorable health consequences. The study highlights the urgent need of effective efforts and strategies for patients' counseling and health education. This can lead to sustainable adoption of preventive behavior.