Background: Stroke is the third leading cause of death and disability globally. After a stroke, neurological deficit leading to dysphagia and physical disability, physiological effects including changes in blood pressure and cerebral salt wasting, as well as investigations and treatments, can all potentially contribute to the development of acute kidney injury (AKI). Furthermore, older, comorbid patients are at greatest risk of AKI. Objective: To investigate the impact of acute kidney injury on prognosis and short-term outcome of patients admitted for acute ischemic stroke. Patients and methods: This was a prospective observational study which was carried out on 100 patients that diagnosed with ischemic stroke and arrived to Emergency Hospital, Mansoura University over a year from June 2019 to June 2020. Results: The average Glasgow coma scale (GCS) among the studied cases was 15. Nearly half of the studied cases developed AKI. The majority of cases were discharged on an Organophosphorus compounds (OPC), while only 29 of which were died. Dead group demonstrated significant increase in serum creatinine after 3 days, AKI development and stay duration more than one week. Demographic characteristics and past history of medical diseases demonstrated insignificant differences among dead and living cases. AKI was demonstrated to be the only significant predator of mortality among the studied cases. AKI was a significant predictor of the survival duration. In contrast, ICU stay and stay duration were not significant predictors of survival. Conclusion: Patients with acute ischemic stroke were at higher possibility for development of AKI, which was accompanied with worse outcomes.