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Background: Polycystic ovary syndrome is a hormonal disorder commonly found in women of reproductive age affecting about 15% of them and is considered the most common cause of anovulatory infertility. Administration of metformin to these anovulatory women increase ovulation rate and continuing in first trimester improves the pregnancy outcome.
Objective: To assess pregnancy outcome in women with polycystic ovary syndrome who continue metformin
during first trimester with its co-morbidity and mortality.
Patients and Methods: This prospective intervention study was conducted on 44 pregnant polycystic ovary syndrome women who were attending for antenatal care at Outpatient Clinic, Obstetric and Gynaecological Department, Zagazig University Hospital. These 44 women took metformin before pregnancy and was followed up by indication of ovulation and metformin (1000-1500 mg/day) until they got pregnant. Then they were divided into two group: group 1 (22) continuous metformin dose during first trimester and group 2 (22) who discontinued metformin therapy once pregnancy diagnosed. The 2 groups followed up by fasting blood glucose and fasting serum insulin at their first visit and at 28 weeks of gestation.
Results: group 1 who continued (1000_1500mg /day) metformin in first trimester had good pregnancy outcomes (significantly lower weight gain, lower gastrointestinal diabetes mellitus and lower spontaneous miscarriage) than group 2 who discontinued metformin (p value: 0.001).
Conclusions: good maternal outcomes in women with polycystic ovary syndrome who continued metformin during first trimester including decrease incidence of spontaneous miscarriage and gastrointestinal diabetes mellitus.
DOI
10.21608/ejhm.2021.148557
Keywords
polycystic ovary syndrome (PCOS), Metformin, spontaneous abortion
Authors
First Name
Azza Abdel Mageid
MiddleName
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Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Egypt.
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Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Egypt.
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-MiddleName
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Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Egypt.
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Mohamed Abdel-Moneim
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Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Egypt.
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m.almeshawy@gmail.com
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https://ejhm.journals.ekb.eg/article_148557.html
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https://ejhm.journals.ekb.eg/service?article_code=148557
Publication Title
The Egyptian Journal of Hospital Medicine
Publication Link
https://ejhm.journals.ekb.eg/
MainTitle
Effects of Metformin on Pregnancy Outcomes in Women with Polycystic Ovary Syndrome during First Trimester