Background: Myxovirus-resistance protein 1 (MXA) is a key mediator of the interferon-induced antiviral response and is tightly regulated by type I IFNs. The expression of type I IFN signaling components is markedly increased in psoriasis skin lesions. The role of MXA in psoriasis pathogenesis is still poorly understood. Objective: The aim was to investigate the role of MXA in psoriatic skin. Material and Methods: Medline databases (PubMed, and Medscape) and all materials available in the internet were searched. The search was performed in December 2020. Study selection: The initial search presented 120 articles. The number of studies that met the inclusion criteria was 17. The articles included diagnosed patients with chronic plaque psoriasis of both genders. Data synthesis: Significant data were collected. Then a structured review was performed. Data extraction: If the studies did not fulfill the inclusion criteria, they were excluded. Data from each eligible study were independently abstracted in duplicate using a data collection form to capture information on study characteristics, interventions, and quantitative results reported for each outcome of interest. Finding: In total 9 potentially relevant publications were included; it was found that cytoplasmic localization of MXA in the keratinocytes of the psoriatic skin might play a private role in psoriasis pathogenesis. Conclusion: Cytoplasmic localization of MXA in the keratinocytes of the psoriatic skin might play a private role in psoriasis pathogenesis. This can open a new gate for a target therapy in psoriasis.