Beta
ManageSearchChatDiscover
144577

Effect of Use of Single Dose of Misoprostol on Blood Loss during Myomectomy

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Background: Uterine leiomyomas are the commonest benign tumours in women, which are estrogen-dependent and grow during the reproductive life. Standard treatment for leiomyoma is hysterectomy or myomectomy according to women's age and fertility. Prostaglandins and particularly PGE1 as misoprostol have an impact on uterine contractions and decrease blood loss.
Objective: To evaluate the effect of using a single dose of vaginal misoprostol (400 Microgram) one hour before abdominal myomectomy on intraoperative blood loss.
Materials and methods: This prospective randomized study was carried out postmenstrual upon 50 women with symptomatic uterine myoma who attended to Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University during the period from October 2019 until October 2020. All subjects were divided into two equal groups: Misoprostol group included 25 women administered 400 mg misoprostol vaginally one hour before operation, and control group included 25 women underwent operation without misoprostol. Outcome variables included: intraoperative blood loss (ml), postoperative hemoglobin values, postoperative hematocrit values and operative time.
Results: there was statistically significant difference between the two studied groups according to amount of intraoperative blood loss (ml) as Misoprostol group showed less blood loss than control group [(308.0 ± 32.66 vs. 404.4 ± 87), with p = 0.001]. In addition, there was statistically significant difference between the two studied groups regarding operative time as Misoprostol group showed shorter duration than control group [(56.8 ± 3.12 vs. 78.6 ± 10.6), with p=0.001].
Conclusion: A single dose of preoperative vaginal misoprostol is an effective method for reducing blood loss and operative time during abdominal myomectomy operations.

DOI

10.21608/ejhm.2021.144577

Keywords

Abdominal myomectomy, blood loss, operative time, Uterine leiomyoma, Vaginal Misoprostol

Authors

First Name

Alaa Elden Fath Alah

Last Name

Alhalaby

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Email

-

City

-

Orcid

-

First Name

Hend Ali

Last Name

Shehl

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Email

-

City

-

Orcid

-

First Name

Heba Maged

Last Name

Abo Shady

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Email

-

City

-

Orcid

-

First Name

Nabih Ibrahim

Last Name

El khouly

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Email

-

City

-

Orcid

-

Volume

82

Article Issue

2

Related Issue

20779

Issue Date

2021-01-01

Receive Date

2021-01-29

Publish Date

2021-01-01

Page Start

296

Page End

301

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 82_Issue 2_Pages 296-301.pdf

PDF . 266.1kB

Link

https://ejhm.journals.ekb.eg/article_144577.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=144577

Order

18

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Effect of Use of Single Dose of Misoprostol on Blood Loss during Myomectomy

Details

Type

Article

Created At

22 Jan 2023