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143897

Association of Apolipoprotein A1 Gene Polymorphism and Coronary Heart Diseases in Patients with Type 2 Diabetes Mellitus

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Last updated: 03 Jan 2025

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Abstract

Background: Type 2 diabetes mellitus (T2DM) is one of the world's most common diseases with a high prevalence and incidence.
Objective: To investigate the association of APOA1 polymorphism (-75 G/A) with dyslipidemia and susceptibility to CAD among Egyptian patients with T2DM.
Patients and Methods: A total number of 72 subjects with T2DM and 72 age and sex matched healthy controls were enrolled for the study. T2DM patients were subdivided to T2DM without CAD (n=36) and T2DM with CAD (n=36). Genotyping of the APOA1 was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) combined with gel electrophoresis, and then confirmed by direct sequencing.
Results: Our findings revealed that GA and AA genotypes and A allele of APOA1 G-75A were significantly higher in controls than T2DM without CAD cases. Also, GA and AA genotypes and A allele of APOA1 G- 75A were significantly higher in controls than T2DM with CAD cases. The risk of CAD were significantly lower among patients carrying GA and AA genotypes than those carrying GG genotype (OR (95%CI): 0.16 (0.06-0.48), P<0.001; OR (95%CI): 0.08 (0.01-0.78), P<0.01, respectively). Our findings revealed significantly higher values of HDL in AA genotype of APOA1 G-75A compared to GA and GG. On the other hand, there were significantly lower values of TC and TG in AA genotype of APOA1 G-75A compared to GA and GG. Conclusions: The individuals with the APOA1 -75 GA and AA genotypes and A allele were likely to have a lower risk of T2DM and CAD as a result of its effect on HDL-C serum levels.

DOI

10.21608/ejhm.2021.143897

Keywords

Apolipoprotein A1, Coronary Artery Disease, Gene polymorphism, T2DM

Authors

First Name

Nearmeen M.

Last Name

Rashad

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First Name

Gehan A.

Last Name

Ebrahem

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First Name

Amal S.

Last Name

El-Shal

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First Name

Mohamed R. H.

Last Name

Abo- Zenar

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First Name

Islam G.

Last Name

Ahmed

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First Name

Mohamed G.

Last Name

Hamed

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Volume

82

Article Issue

2

Related Issue

20779

Issue Date

2021-01-01

Receive Date

2021-01-27

Publish Date

2021-01-01

Page Start

289

Page End

295

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 82_Issue 2_Pages 289-295.pdf

PDF . 429.7kB

Link

https://ejhm.journals.ekb.eg/article_143897.html

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https://ejhm.journals.ekb.eg/service?article_code=143897

Order

17

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Association of Apolipoprotein A1 Gene Polymorphism and Coronary Heart Diseases in Patients with Type 2 Diabetes Mellitus

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Article

Created At

22 Jan 2023