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143886

The Possible Radio Protective Role of Gum Arabic on The Kidney Cortex of Adult Male Albino Rats

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Last updated: 24 Dec 2024

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Abstract

Aim of the work: the use of ionizing radiation exposure increases, oxidative stress especially for cancer patients. Therefore, there is a critical need to develop antioxidants that prevent oxidative stress damage. Gum Arabic is an antioxidant and anti-inflammatory mediator. This study aimed to assess the possible radio protective effect of gum Arabic (Acacia senegal) against gamma irradiation-induced injury on the rat kidney. Materials and Methods: four groups of male Albino rats (each of 12 rats) received normal saline (G1), dose 5Gy of gamma irradiation (G2), orally administered with 25 mg/kg gum Arabic for 3 weeks (G3) and gamma irradiation plus oral gum Arabic administration for 7 days before and 21 days after irradiation (G4). Results: in the gamma irradiated group, histopathological and ultrastructural examinations of the rat kidney cortical tissue revealed signs of degeneration to the cortical renal tubules and glomeruli. In contrast, gum Arabic treatment alleviated most of the damaging effects of gamma radiation. Conclusion: oral administration of gum Arabic could ameliorate adverse gamma radiation-induced effects that might be attributed to its antioxidative and free radical scavenging effects.

DOI

10.21608/ejhm.2021.143886

Keywords

gamma radiation, kidney, Gum Arabic, radio protective, Rats

Authors

First Name

Heba Ahmed Mohamed

Last Name

Kandeal

MiddleName

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Affiliation

Zoology Department, Faculty of Science, Al-Azhar University, Egypt

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Orcid

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First Name

Fatma Ahmed

Last Name

Eid

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Al-Azhar University, Egypt

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Orcid

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First Name

Hemmat Mansour

Last Name

Abdelhafez

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Al-Azhar University, Egypt

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Orcid

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First Name

Amr Mahmoud

Last Name

Abd El-Hady

MiddleName

-

Affiliation

Faculty of Applied Medical Sciences, Misr University for Science and Technology (MUST), Egypt

Email

amreem2005@yahoo.com

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Orcid

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Volume

82

Article Issue

2

Related Issue

20779

Issue Date

2021-01-01

Receive Date

2021-01-27

Publish Date

2021-01-01

Page Start

256

Page End

269

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 82_Issue 2_Pages 256-269.pdf

PDF . 1.3MB

Link

https://ejhm.journals.ekb.eg/article_143886.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=143886

Order

13

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

The Possible Radio Protective Role of Gum Arabic on The Kidney Cortex of Adult Male Albino Rats

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Article

Created At

22 Jan 2023