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140446

Myocardial Protection with Glucose-Insulin-Potassium Infusion during Cardiopulmonary Bypass for Coronary Revascularization

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Last updated: 03 Jan 2025

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Abstract

Background: Sodi-Pallares and colleagues first time introduced use of glucose-insulin and potassium (GIK) solution for myocardial protection. They used this solution in patients with acute myocardial infarction and concluded that GIK solution limited electrocardiographic changes in these patients.
Objective: To investigate the effectiveness of the GIK solution regarding myocardial protection evaluated by postoperative creatine kinase MB (CKMB) and cardiac troponin I levels.
Method: In this prospective, randomized clinical trial, sixty-four patients were assigned into two groups: GIK group, in which glucose-insulin and potassium infusion were given during surgery, and non-GIK group in which only saline infusion was given during the procedure.
Results: All CK-MB values were lower in the GIK group than the Non-GIK group in the postoperative period (6, 12 and 24 hours' samples) with statistically significant results. Troponin values were lower in the GIK group versus the Non-GIK group after 6 and 12 hours with statistical significance (P < 0.001 and 0.022 respectively). Conclusion: The addition of GIK infusion throughout the operation to standard myocardial protective techniques in patients undergoing on-pump coronary artery bypass graft (CABG) surgery attenuates myocardial ischemic injury.

DOI

10.21608/ejhm.2021.140446

Keywords

CABG, cardiac protection, Inotropic support, GIK

Authors

First Name

Essam Ezzat

Last Name

Abd El-Hakeem

MiddleName

-

Affiliation

Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Assiut University

Email

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Orcid

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First Name

Ahmed Elsaied Abd Elrahman

Last Name

Aly

MiddleName

-

Affiliation

Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Sohag University, Egypt

Email

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City

-

Orcid

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First Name

Osama Salah El Din

Last Name

Mahmoud

MiddleName

-

Affiliation

Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Sohag University, Egypt

Email

osamasalah@med.sohag.edu.eg

City

-

Orcid

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First Name

Ahmad Hamody

Last Name

Hassan

MiddleName

-

Affiliation

Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Sohag University, Egypt

Email

-

City

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Orcid

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Volume

82

Article Issue

2

Related Issue

20779

Issue Date

2021-01-01

Receive Date

2021-01-17

Publish Date

2021-01-01

Page Start

212

Page End

216

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 82_Issue 2_Pages 212-216.pdf

PDF . 421.5kB

Link

https://ejhm.journals.ekb.eg/article_140446.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=140446

Order

6

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Myocardial Protection with Glucose-Insulin-Potassium Infusion during Cardiopulmonary Bypass for Coronary Revascularization

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Article

Created At

22 Jan 2023