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140440

Genotyping and Severity of Rotavirus Infection among Infants and Children with Acute Diarrhea

Article

Last updated: 30 Jan 2023

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Abstract

Introduction: Rotavirus (RV) belongs to the Reoviridae virus family and the virion comprises of three concentric protein layers. Worldwide, rotavirus (RV) is the most common cause of severe gastroenteritis (G.E.) among infants and young children especially in those countries which has not launched a RV vaccination program and approximately 40% of hospitalized patients suffering from gastroenteritis were infected with RV. Objective: To determine the prevalence of rotavirus infections, genotypes and degree of severity of its acute diarrhea in infants and children attending the children hospital, at Zagazig University Hospitals. Patients and methods: this study was done on 140 patients admitted to Children Hospital, Zagazig University suffering of gastroenteritis, Vesikari clinical severity score was done and stool sample was taken from patients, which was tested for RV by dipstick method and positive patients underwent genotyping by immunochromatography using PCR technique.
Results: Among the studied group 128 patients (91.4%) showed positive results for rotavirus detection by dipstick analysis of stool, while only 12 patients (8.6%) were negative. The Vesikari score of severity ranged from 9 to 15 with median of 12 and its mean ± SD was 11.9±1.3. G3 and P8 were the most types in the examined patients.
Conclusion: rotavirus is still the main cause of severe gastroenteritis that requires hospital admission. G3 and P8 are the most detectable genotypes.

DOI

10.21608/ejhm.2021.140440

Keywords

diarrhea, Genotyping, Infants and Children, Rotavirus

Authors

First Name

Manar

Last Name

Fathy

MiddleName

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Affiliation

Department of Pediatrics, Faculty of Medicine, Zagazig University

Email

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City

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Orcid

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First Name

Rania m

Last Name

Amer

MiddleName

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Affiliation

Department of Microbiology and Immunology, Faculty of Medicine, Zagazig University

Email

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City

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Orcid

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First Name

Mohamed A

Last Name

Almalky

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Zagazig University

Email

drmohamedalmalkyped@yahoo.com

City

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Orcid

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First Name

Sherif

Last Name

El Gebaly

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Zagazig University

Email

-

City

-

Orcid

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Volume

82

Article Issue

2

Related Issue

20779

Issue Date

2021-01-01

Receive Date

2021-01-17

Publish Date

2021-01-01

Page Start

205

Page End

211

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 82_Issue 2_Pages 205-211.pdf

PDF . 622.4kB

Link

https://ejhm.journals.ekb.eg/article_140440.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=140440

Order

5

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

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Article

Created At

22 Jan 2023