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140431

The Role of Helicobacter Pylori Infection in Idiopathic Thrombocytopenic Purpura in Children

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Last updated: 24 Dec 2024

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Abstract

Background: Many studies had found obvious relation between helicobacter pylori infection and chronic idiopathic thrombocytopenic purpura; several studies have reported remission of immune thrombocytopenic purpura (ITP) after eradication of a coexistent Helicobacter pylori infection in adults, data in children are limited.
Objective: To detect the association of H. pylori infection and idiopathic thrombocytopenic purpura in children and the effect of eradication of the infection on platelet count in these patients.
Patients and methods: This study was conducted on 83 chronic idiopathic thrombocytopenic purpura children with age range from 3 to 13 years. They were 46 males 37 females. Also the study included 104 healthy individual with the same range of age. They were 58 males and 46 females as a control group. This was between October 2018 and September 2019 in the Pediatric Hematology and GIT Clinics or inpatients wards of Pediatric Department.
Results: Clinical benefit occurred in 31 cases of the 83 chronic ITP (cITP) patients screened; nevertheless, we have a simple, inexpensive, nonā€invasive screening method; the adverse events of eradication therapy are negligible, together with an affordable cost, all uncommon attributes among the specific treatments currently available for cITP; therefore it is worthwhile to test for and treat H. pylori infection.
Conclusion: Our data showed a prevalence of H. pylori infection in cITP pediatrics that was similar to other studies. We found that successful H. pylori eradication induced platelet response in 37.3% of 83 cases included in our study.

DOI

10.21608/ejhm.2021.140431

Keywords

H. pylori, Immune thrombocytopenic purpura, platelet count

Authors

First Name

Al Zahraa Elsayed

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Sohag University

Email

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City

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Orcid

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First Name

Ashraf Mahmoud

Last Name

Radwan

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Sohag University

Email

-

City

-

Orcid

-

First Name

Heba Latif

Last Name

Rizk

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Sohag University

Email

hebalatif90@gmail.com

City

-

Orcid

-

Volume

82

Article Issue

2

Related Issue

20779

Issue Date

2021-01-01

Receive Date

2021-01-17

Publish Date

2021-01-01

Page Start

193

Page End

198

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 82_Issue 2_Pages 193-198.pdf

PDF . 689.8kB

Link

https://ejhm.journals.ekb.eg/article_140431.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=140431

Order

3

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

The Role of Helicobacter Pylori Infection in Idiopathic Thrombocytopenic Purpura in Children

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Article

Created At

22 Jan 2023