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140422

Immunohistochemical Expression of Heparanase-2 in Psoriasis

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Last updated: 03 Jan 2025

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Abstract

Background: Psoriasis is a chronic, inflammatory immune mediated skin disease characterized by dense infiltrates of immunocytes especially macrophages. Cross talk between immunocytes and keratinocytes is thought to mediate the disease. Hparanase 2 inhibits activity of Heparanase 1 which is involved in this cross talk by degradation of heparin sulphate chains in the basement membrane and extra cellular matrix (ECM).
Objective: To assess the of Heparanase2 in psoriasis through its immunohistochemical expression in lesional and perilesional skin of psoriasis patients.
Patients and Methods: This prospective case control study was carried out on a total number of 60 subjects, they included 30 patients with chronic plaque psoriasis and 30 age and gender matched apparently normal subjects as control group. Skin biopsies were taken for immunohistochemical evaluation of Heparanase 2 expression. Results: Our results showed significant difference between lesional, perilesional and control groups regarding the status of epidermal Heparanase 2 expression (P = 0.038). All lesional epidermal expression was negative while perilesional epidermal expression was negative in 24 (80%) cases and positive in 6 (20%) cases, control epidermal expression was negative in 27 (90%) cases and positive in 3 (10%) cases. There was no significant difference between the three studied groups regarding dermal Heparanase 2 expression (P = 0.318).
Conclusion: Downregulation of Heparanase 2 could be incriminated in the pathogenesis of psoriasis. Heparanase 2 could have a protective role in skin.

DOI

10.21608/ejhm.2021.140422

Keywords

Heparanase2, Psoriasis, Downregulation, protective

Authors

First Name

Rehab Monir

Last Name

Samaka

MiddleName

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Affiliation

Department of Pathology, Faculty of Medicine, Menoufia University, Shebin El Kom, Menoufia Governorate

Email

rehabsamaka@yahoo.com

City

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Orcid

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First Name

Mohammed Abd Elmoneim

Last Name

Shoieb

MiddleName

-

Affiliation

Department of Dermatology, Faculty of Medicine, Menoufia University, Shebin El Kom, Menoufia Governorate

Email

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City

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Orcid

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First Name

Walaa Adel

Last Name

Abdo

MiddleName

-

Affiliation

Dermatology Department, Sammanud Central Hospital, Gharbeya Governorate Egypt.

Email

walaa_adel9@yahoo.com

City

-

Orcid

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Volume

82

Article Issue

1

Related Issue

20276

Issue Date

2021-01-01

Receive Date

2021-01-17

Publish Date

2021-01-01

Page Start

174

Page End

180

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 82_Issue 1_Pages 174-180.pdf

PDF . 641.5kB

Link

https://ejhm.journals.ekb.eg/article_140422.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=140422

Order

29

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Immunohistochemical Expression of Heparanase-2 in Psoriasis

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Article

Created At

22 Jan 2023