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Background: Cisplatin is antineoplastic drug associated with hepatotoxicity due to oxidative stress. Resveratrol has antioxidant effect so it could protect the liver cell. Objective: the aim of this work was to investigate the possible protective effects of resveratrol on hepatotoxicity caused by cisplatin drug in rats.
Materials and Methods: forty male albino rats were randomly divided into four groups: group I (control group): was maintained throughout the experiment without any treatment. Group II (resveratrol group) that received resveratrol daily in a dose of 25 mg/kg intraperitoneally for 21 days. Group III (cisplatin group) that received single intraperitoneal injection of cisplatin in a dose of 7.5 mg/kg at the 16th day of the experiment. Group IV (protected group) that received resveratrol in a dose of 25 mg/kg intraperitoneally for 21 days and cisplatin at 16th day of the experiment. Body and liver weight were estimated, biochemical measurements and histopathological study of the liver tissue were done.
Results: showed significant preservation of the liver function and histological structure.
Conclusion: it is concluded that resveratrol could protect liver against cisplatin side effects.
DOI
10.21608/ejhm.2021.139651
Keywords
Cisplatin, liver toxicity, Resveratrol
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drnohaissa@yahoo.com
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https://ejhm.journals.ekb.eg/article_139651.html
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https://ejhm.journals.ekb.eg/service?article_code=139651
Publication Title
The Egyptian Journal of Hospital Medicine
Publication Link
https://ejhm.journals.ekb.eg/
MainTitle
The Adjuvant Protective Effect of Resveratrol on Cisplatin-Induced Liver Toxicity in Male Albino Rats