Beta
ManageSearchChatDiscover
139646

Organoprotective Effect of Remote Ischemic Preconditioning during Living Donor Liver Transplantation, A Prospective Randomized Double-Blinded Study

Article

Last updated: 30 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Background: Ischemia reperfusion injury (IRI) during liver transplantation carries a substantial risk for graft damage, and other major organ injury. Strategies to minimize IRI in the grafted liver are of paramount importance. Remote ischemic preconditioning (RIP) is a recently described technique that can offer a liver protective effect against IRI.
Patients and Methods: In this prospective randomized study, consent was obtained from 80 couples (donorā€“ recipient) prepared for liver transplantation (LT). Patients were divided randomly (using closed envelope technique) into two groups: RIP group (n=35) as RIP procedure was run in the donor non-dominant hand just at the start of parenchymal transection and control group (n= 35). In all the study cases, the pressure cuff was wrapped around the recipient arm. In RIP group, four sets of 5 minutes manual pressure cuff elevation to 200 mmHg, separated by 5 minutes of release (Using the non-dominant hand).
Results: No statistically significant difference was found between the biochemical profile (SGPT, CRP, and bilirubin) of the recipients in both of the study groups. Similarly, post-operative kidney function (Serum creatinine) was comparable findings in the two studied groups.
Conclusion: RIP in living donor liver transplantation failed to show a protective effect neither on the graft response to reperfusion injury, nor the on the postoperative kidney functions. Future studies are recommended taking into consideration histopathological, tissue damage scores.

DOI

10.21608/ejhm.2021.139646

Keywords

Liver transplantation, Preconditioning, reperfusion, Organ protection

Authors

First Name

Alrefaey K

Last Name

Alrefaey

MiddleName

-

Affiliation

Department of Anesthesia and Surgical Intensive Care, Faculty of Medicine, Mansoura University, Egypt

Email

-

City

-

Orcid

-

First Name

Mohammed A

Last Name

Elmorshedi

MiddleName

-

Affiliation

Department of Anesthesia and Surgical Intensive Care, Faculty of Medicine, Mansoura University, Egypt

Email

-

City

-

Orcid

-

First Name

Usama A

Last Name

Elsayed

MiddleName

-

Affiliation

Department of Anesthesia and Surgical Intensive Care, Faculty of Medicine, Mansoura University, Egypt

Email

-

City

-

Orcid

-

Volume

82

Article Issue

1

Related Issue

20276

Issue Date

2021-01-01

Receive Date

2021-01-14

Publish Date

2021-01-01

Page Start

150

Page End

155

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 82_Issue 1_Pages 150-155.pdf

PDF . 524.7kB

Link

https://ejhm.journals.ekb.eg/article_139646.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=139646

Order

26

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023