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139639

The Prognostic Role of Β-Catenin Subcellular Localization in Hepatocellular Carcinoma of Egyptian Patients

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Last updated: 24 Dec 2024

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Abstract

Background: Hepatocellular carcinoma (HCC) is one of the most common cancers in Egypt with fatal outcome. The molecular pathogenesis of this type of cancer is so complex involving interaction of several signaling pathways. Among those is Wingless (WNT)/β-catenin signaling pathway, which is frequently activated in HCC.
Objectives: To investigate the relationship of different localization patterns of β-catenin in relation to different histopathologic parameters in Egyptian HCC cases.
Patients and methods: One hundred and twenty-one (121) HCC specimens were subjected for β-catenin evaluation by immunohistochemistry.
Results: The studied HCC cases showed β-catenin membranous expression in 47/121 (38.8%) of cases, while nucleocytoplasmic localization was observed in 31/121 (25.6%). Most of HCC cases that showed single tumor mass presentation exhibited negative nucleocytoplasmic expression pattern (79.2%, P=0.02). Membranous pool of β-catenin was associated with adverse prognostic factors like increased positivity among high-grade cases (P=0.04), higher H score value in cases having lymphovascular invasion, positive lymph node and higher (advanced) TMN stages (P = 0.01, 0.00, 0.00 &0.03 respectively).
Conclusion: HCC cases showed heterogeneous β-catenin expression pattern. Membranous β-catenin localization was associated with aggressive prognostic parameters of HCC.

DOI

10.21608/ejhm.2021.139639

Keywords

β-catenin, Subcellular localization, HCC, Immunohistochemistry

Authors

First Name

Rania Abdallah

Last Name

Abdallah

MiddleName

-

Affiliation

Pathology Department, Faculty of Medicine, Menoufia University, Shebin El Kom, Menoufia Governorate,

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Orcid

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First Name

Dalia Refaat

Last Name

Al-Sharaky

MiddleName

-

Affiliation

Pathology Department, Faculty of Medicine, Menoufia University, Shebin El Kom, Menoufia Governorate,

Email

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City

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Orcid

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First Name

Doha Maher

Last Name

Taie

MiddleName

-

Affiliation

Pathology Department, National Liver Institute, Menoufia University, Shebin El Kom, Menoufia Governorate, Egypt

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City

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Orcid

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First Name

Marwa Said

Last Name

EL Masry

MiddleName

-

Affiliation

Pathology Department, National Liver Institute, Menoufia University, Shebin El Kom, Menoufia Governorate, Egypt

Email

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City

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Orcid

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First Name

Rehab Monir

Last Name

Samaka

MiddleName

-

Affiliation

Pathology Department, Faculty of Medicine, Menoufia University, Shebin El Kom, Menoufia Governorate,

Email

rehabsamaka@yahoo.com

City

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Orcid

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Volume

82

Article Issue

1

Related Issue

20276

Issue Date

2021-01-01

Receive Date

2021-01-14

Publish Date

2021-01-01

Page Start

129

Page End

136

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 82_Issue 1_Pages 129-136.pdf

PDF . 887.7kB

Link

https://ejhm.journals.ekb.eg/article_139639.html

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https://ejhm.journals.ekb.eg/service?article_code=139639

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

The Prognostic Role of Β-Catenin Subcellular Localization in Hepatocellular Carcinoma of Egyptian Patients

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Type

Article

Created At

22 Jan 2023