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137968

Acute Graft-versus-Host Disease: An Immunologic Perspective

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Last updated: 30 Jan 2023

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Abstract

Background: Acute graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell transplant (AHscT) is an immune triggered process, leading to profound immune dysregulation and organ dysfunction. Three phases summarize the development of the immunopathophysiology of acute GVHD: an afferent phase, an efferent phase and an effector phase. A panel of plasma biomarkers including IL-2-receptor-a, TNF receptor-1, IL-8, and hepatocyte growth factor has been suggested as a confirmatory tool for the diagnosis of acute GVHD at the onset of clinical symptoms and to provide prognostic information independent of GVHD severity. Initial therapy for acute GVHD ranges from a simple observation or a trial of topical corticosteroids for skin GVHD of stage Ι or ΙΙ, to systemic treatment in patients with grade ΙΙ-ΙV acute GVHD.
Objectives: The aim of this work is to summarize the most recent available data concerning acute graft versus host disease from biology, immunopathogenesis, diagnosis and therapy.
Material and Methods: We searched the PubMed and Google scholar databases for relevant studies acute graft-versus-host disease an immunologic perspective.
Conclusion: Acute graft versus host disease (aGVHD) remains the second leading cause of death following allogeneic hematopoietic stem cell transplant (AHSCT). Over the last five years, the progress in understanding the pathophysiology of this immune based-process helped redefine graft versus host reaction and opened new possibilities for novel preventive and therapeutic approaches.

DOI

10.21608/ejhm.2021.137968

Keywords

Bone Marrow Transplantation, Acute versus host disease

Authors

First Name

Sabry A.

Last Name

Shoeib

MiddleName

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Affiliation

Department of Internal Medicine, Faculty of Medicine, Menoufia University

Email

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City

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Orcid

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First Name

Alaa E.

Last Name

Abd El-Hamid

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine, Menoufia University

Email

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City

-

Orcid

-

First Name

Enas S.

Last Name

Zahran

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine, Menoufia University

Email

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City

-

Orcid

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First Name

Noha I.A.

Last Name

El-Mowafy

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine, Menoufia University

Email

nohamowafy933@gmail.com

City

-

Orcid

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Volume

82

Article Issue

1

Related Issue

20276

Issue Date

2021-01-01

Receive Date

2021-01-10

Publish Date

2021-01-01

Page Start

96

Page End

100

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 82_Issue 1_Pages 96-100.pdf

PDF . 607.4kB

Link

https://ejhm.journals.ekb.eg/article_137968.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=137968

Order

17

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

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Article

Created At

22 Jan 2023