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137953

Body Mass Index in Systemic Lupus Erythematosus: Relation to Disease Activity, Bone Mineral Density And Vitamin D Level

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Last updated: 03 Jan 2025

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Abstract

Background: High incidence of obesity has been reported in Systemic Lupus Erythematosus (SLE). However, the relationship between obesity and SLE is still unclear. Studies reported low vitamin D levels and bone mineral density (BMD) in SLE patients. Moreover, vitamin D plays a vital role in the pathogenesis and complication of SLE.
Objective: To investigate the link between increased body mass index (BMI), disease activity, BMD, and vitamin D level in SLE patients .
Patients and Methods:120 SLE patients were classified according to BMI into three groups, normal BMI (<25 kg/m2), overweight (25ā€“29.9 kg/m2), and obese (>30 kg/m2). Laboratory investigations were done, assessment of disease activity by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), measuring the serum levels of 25-hydroxyvitamin D 25(OH) D were assessed.
Results: 30% were overweight, and 45% were obese. Overweight and Obese patients had lower 25(OH) D levels and a high prevalence of osteoporosis in comparison to patients with normal BMI. SLEDAI score was positively correlated to BMI and negatively correlated with 25(OH) D and BMD.
Conclusion: Increased BMI is common in SLE and is independently associated with higher disease activity, osteoporotic rates, and lower 25 (OH) vitamin D levels. These findings are associated with important clinical implications, which suggests that weight control may be a potential target for improving SLE outcome.

DOI

10.21608/ejhm.2021.137953

Keywords

Bone Mineral Density, Obesity, Systemic lupus erythematosus, Vitamin D

Authors

First Name

Dalia A.

Last Name

El-Sherbiny

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First Name

Mohja A.

Last Name

El-Badawy

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First Name

Amira R.

Last Name

Elmahdi

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Volume

82

Article Issue

1

Related Issue

20276

Issue Date

2021-01-01

Receive Date

2021-01-10

Publish Date

2021-01-01

Page Start

89

Page End

95

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 82_Issue 1_Pages 89-95.pdf

PDF . 667.0kB

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https://ejhm.journals.ekb.eg/article_137953.html

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https://ejhm.journals.ekb.eg/service?article_code=137953

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16

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Body Mass Index in Systemic Lupus Erythematosus: Relation to Disease Activity, Bone Mineral Density And Vitamin D Level

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Article

Created At

22 Jan 2023